OK, I read through the entire study in "Vaccines", somewhat mind- and eye-numbing, lots of rereading the previous sentence (sometimes a few times) but I have a medical background so I was able to slog through it and, as suggested by our fearless leader, it WAS totally worth it to get to the end and find that they were suggesting that mRN…
OK, I read through the entire study in "Vaccines", somewhat mind- and eye-numbing, lots of rereading the previous sentence (sometimes a few times) but I have a medical background so I was able to slog through it and, as suggested by our fearless leader, it WAS totally worth it to get to the end and find that they were suggesting that mRNA vaccines might have "at least 6 negative unintended consequences". Here are my shortened versions of the 6 plus a final sort of coda:
1. "...even these less pathogenic Omicron subvariants could cause significant harm and even death in individuals with comorbidities and immuno-compromised conditions."
2. "...this immune suppression could allow the re-activation of latent viral, bacterial, or fungal infections and might also allow the uncontrolled growth of cancer cells..."
3. "A tolerant immune system might allow SARS-CoV-2 persistence in the host and promote the establishment of a chronic infection, similar to that generated by the hepatitis B virus (HBV), the human immune deficiency virus (HIV), and the hepatitis C virus (HCV)..." Long Covid, anyone? (my words)
4. "The combined immune suppression (produced by SARS-CoV-2 infection ... and further enhanced by vaccination ... could explain a plethora of autoimmune conditions, such as cancers, re-infections, and deaths temporally associated with both. It is conceivable that the excess deaths reported in several highly COVID-19-vaccinated countries may be explained, in part, by this combined immunosuppressive effect."
5. "... it is probable that the spike protein produced in response to mRNA vaccination is too high and lasts too long in the body. That could overwhelm the capacity of the immune system, leading to autoimmunity ... . Indeed, several investigations have found that COVID-19 immunization is associated with the development of autoimmune responses"
6. "... it is plausible to suggest that excessive vaccination could be associated with the occurrence of an increased number of myocarditis cases and sudden cardiac deaths."
This last paragraph is not numbered but is quite a summation:
"Finally, these negative outcomes are not expected to affect all people who have received these mRNA vaccines. Individuals with genetic susceptibility, immune deficiencies, and comorbidities are probably the most likely to be affected. However, this gives rise to a disturbing paradox—if people who are the most affected by the COVID-19 disease (the elderly, diabetics, hypertensive, and immunocompromised people like those with HIV) are also more susceptible to suffering the negative effects of repeated mRNA vaccination, is it then justified to booster them? As Omicron subvariants have been demonstrated to be less pathogenic [133,134,135,136,137], and mRNA vaccines do not protect against re-infection [14,138], clinicians should be aware of the possible detrimental effects on the immune system by administering boosters."
Finally, these negative outcomes are not expected to affect all people who have received these mRNA vaccines. Individuals with genetic susceptibility, immune deficiencies, and comorbidities are probably the most likely to be affected. However, this gives rise to a disturbing paradox—if people who are the most affected by the COVID-19 disease (the elderly, diabetics, hypertensive, and immunocompromised people like those with HIV) are also more susceptible to suffering the negative effects of repeated mRNA vaccination, is it then justified to booster them? As Omicron subvariants have been demonstrated to be less pathogenic [133,134,135,136,137], and mRNA vaccines do not protect against re-infection [14,138], clinicians should be aware of the possible detrimental effects on the immune system by administering boosters.
OK, I read through the entire study in "Vaccines", somewhat mind- and eye-numbing, lots of rereading the previous sentence (sometimes a few times) but I have a medical background so I was able to slog through it and, as suggested by our fearless leader, it WAS totally worth it to get to the end and find that they were suggesting that mRNA vaccines might have "at least 6 negative unintended consequences". Here are my shortened versions of the 6 plus a final sort of coda:
1. "...even these less pathogenic Omicron subvariants could cause significant harm and even death in individuals with comorbidities and immuno-compromised conditions."
2. "...this immune suppression could allow the re-activation of latent viral, bacterial, or fungal infections and might also allow the uncontrolled growth of cancer cells..."
3. "A tolerant immune system might allow SARS-CoV-2 persistence in the host and promote the establishment of a chronic infection, similar to that generated by the hepatitis B virus (HBV), the human immune deficiency virus (HIV), and the hepatitis C virus (HCV)..." Long Covid, anyone? (my words)
4. "The combined immune suppression (produced by SARS-CoV-2 infection ... and further enhanced by vaccination ... could explain a plethora of autoimmune conditions, such as cancers, re-infections, and deaths temporally associated with both. It is conceivable that the excess deaths reported in several highly COVID-19-vaccinated countries may be explained, in part, by this combined immunosuppressive effect."
5. "... it is probable that the spike protein produced in response to mRNA vaccination is too high and lasts too long in the body. That could overwhelm the capacity of the immune system, leading to autoimmunity ... . Indeed, several investigations have found that COVID-19 immunization is associated with the development of autoimmune responses"
6. "... it is plausible to suggest that excessive vaccination could be associated with the occurrence of an increased number of myocarditis cases and sudden cardiac deaths."
This last paragraph is not numbered but is quite a summation:
"Finally, these negative outcomes are not expected to affect all people who have received these mRNA vaccines. Individuals with genetic susceptibility, immune deficiencies, and comorbidities are probably the most likely to be affected. However, this gives rise to a disturbing paradox—if people who are the most affected by the COVID-19 disease (the elderly, diabetics, hypertensive, and immunocompromised people like those with HIV) are also more susceptible to suffering the negative effects of repeated mRNA vaccination, is it then justified to booster them? As Omicron subvariants have been demonstrated to be less pathogenic [133,134,135,136,137], and mRNA vaccines do not protect against re-infection [14,138], clinicians should be aware of the possible detrimental effects on the immune system by administering boosters."
Finally, these negative outcomes are not expected to affect all people who have received these mRNA vaccines. Individuals with genetic susceptibility, immune deficiencies, and comorbidities are probably the most likely to be affected. However, this gives rise to a disturbing paradox—if people who are the most affected by the COVID-19 disease (the elderly, diabetics, hypertensive, and immunocompromised people like those with HIV) are also more susceptible to suffering the negative effects of repeated mRNA vaccination, is it then justified to booster them? As Omicron subvariants have been demonstrated to be less pathogenic [133,134,135,136,137], and mRNA vaccines do not protect against re-infection [14,138], clinicians should be aware of the possible detrimental effects on the immune system by administering boosters.
Thanks for slogging through. This would have never survived peer review/publishers a couple of years ago.